"The next time you get to the MSA field when submitting your press release and it says "Your release is currently targeting All Regions/International and the following Cities / MSAs:" take your top keyword or keyword term and use Google trends to see where in the US or worldwide you can add to your targeted region.
Say you own a web site dedicated to selling after market Jeep car parts, for example, and you are about to send out a press release about a new product line your will be carrying. Before you send out the press release go to Google Trends and search "Jeep".
Now it is essential to refine your search. Make sure to select your region and time scale. I always try to select "Last 30 days" so I get the most relevant results.
After narrowing down the search it will shoot out the top searched cities for your keyword of "Jeep". If your keyword or terms comes back with no results, try to simplify them until you get results.
As you can see Denver, CO and Phoenix, AZ are the top results. To find out more about how Google calculates the top results, read this excerpt from Google Trends FAQ:
For counting and ranking cities, Google Trends first looks at a sample of all Google searches to determine the cities from which we received the most searches for your first term. Then, for those top cities, Google Trends calculates the ratio of searches for your term coming from each city divided by total Google searches coming from the same city. The city ranking you see on the page and the bar charts alongside each city name both represent this ratio. When cities' ratios are fairly close together, the corresponding bar graphs will be roughly the same length, and the exact ranking between these cities is less meaningful.
So, I should include them in the MSA field when submitting the press release.
After you have filled out everything else correctly, submit the press release and watch the targeting work its magic."
For the entire article, read evisibility.